The disease matching score is determined using the following parameters:
For each gene, the maximal score of all the above mentioned possible scores is used as the final gene score. The final disease score is based on the final scores of all the matched genes.
All matched diseases are presented in descending order of their score. If several matches have the same score, they are ordered by the ratio of matched to total number of genes in the disease (from highest to lowest).
The disease section in GeneAnalytics contains four powerful filters which enable you to focus on specific sub-sets of the results:
Gene-disease relations: filtration of diseases that have either differentially expressed genes or genes with genetic association to the disease. Read more on gene-disease relations.
Genetic association type: filtration of diseases that have genes with genetic association to the disease.
Disease categories: filtration of diseases in accordance with the MalaCards disease categorization. Read more about disease categorization.
GeneAnalytics disease results are derived from information available in Malacards. The Malacards algorithm categorizes each disease into up to four anatomical categories and/or up to five global categories, based on:
Please note that not all the diseases in the detailed results table are categorized.