In the tissues & cells section, the matching algorithm relies on gene annotations of each gene in each entity available in LifeMap Discovery®. These annotations are derived from the scientific literature and/or on bioinformatics calculations executed on expression data in LifeMap Discovery.
Each gene can have one or more of the following annotations:
Each gene in each entity is scored, based on both the entity type and the combination of the above mentioned annotations of that particular gene in the specific entity.
|Query size||Entity score||Tissue/system score|
|1 gene||=Gene score||The maximal gene score among all genes in the tissue/system.|
|>1 gene||A weighted sum of the scores of all genes matched to this entity, normalized to log of the maximal score that can be potentially achieved for the entity||A weighted sum of the scores of all genes matched to this tissue/system, normalized to log of the maximal score that can be potentially achieved for the tissue/system|
The matching score is calculated at three levels: the entity, the tissue and the system. The calculation procedure is different between a single-gene query and larger queries:
All matched genes are presented in descending order of their score. If several matches have the same score, they are ordered by the ratio of matched to total number of genes in the entity (from highest to lowest). In single-gene queries, in vivo entities will appear before in vitro entities with the same score.